Endocrine Abstracts

Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves’ ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor-β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO.Methods: The following ...

The role of genetic factors in the pathogenesis of Graves’ disease (GD) is not clear. The purpose of this study was to investigate the association between single nucleotide polymorphisms in pro-inflammatory cytokine genes and GD in Iranian patients. A case–control hospitalbased study was carried out on 107 GD patients and 140 healthy controls. Cytokine typing was performed by PCR with sequence-specific primers (PCR-SSP) assay. The allele and genotype frequencies of t...